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Vyntus IOS

IOS Impulse Oscillometry
Tidal breathing analysis with Impulse Oscillometry (IOS) has demonstrated to be informative and differentiated in the early detection and follow up of pulmonary diseases like asthma, COPD and idiopathic pulmonary fibrosis. IOS is almost independent of patient cooperation and can test a larger patient range than spirometry alone, from children to adult to geriatric patients.

IOS is available as a stand-alone device combined with a spirometry measurement program (MasterScreen IOS and Vyntus IOS) or as an add-on module to the MasterScreen series.

  • Spirometric and airway resistance diagnostics in one device.
  • Assessment and differentiation of airway function under quiet breathing conditions.
  • Allows testing children < 5 years of age.
  • Automated Quality Management System for best results with multi trial concept
  • Sensitive and early detection of pulmonary obstruction.
  • Allows differentiation of central and peripheral airways by measuring airway resistance and reactance at multiple frequencies.
  • More sensitive in detecting response to drug therapy than FEV1 alone.
  • Excellent for bronchial provocation monitoring.
  • Classification of small airway severity and interpretation of test results
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Features & Benefits

  • Assessment and differentiation of airway function under quiet breathing conditions.
  • Sensitive and early detection of pulmonary obstruction. Asthma patients may be asymptomatic with normal spirometry and still show levels of increased airway resistance. IOS measures impedance at different frequencies indicative of central and peripheral airway resistance.
  • Allows differentiation of central (proximal) airways resistance and peripheral (distal) airways resistance.
  • Bronchodilator therapy often does not reach the peripheral airways. IOS can provide objective response to drug therapy even when FEV1 can’t.
  • Monitor the effect of bronchial provocation on airway tone.
  • Automatic classification and interpretation of results with SentrySuite software.

How does IOS work?

The oscillations of the multi- frequency measurement signal penetrate the respiration tract at varying depths. Whereas 20 Hz signals are absorbed (shunted) in the large airways, 5 Hz oscillations penetrate the entire lung. Thus, the respiratory resistance Rrs of the large airways can be differentiated from the lung reactance Xrs of the small airways.

  • Impulse oscillometry and plethysmography should be considered the preferred techniques for measuring bronchodilation in COPD Clinical Trials¹
  • Several forced oscillation measures are more accurate and sensitive for detecting bronchodilator response than FEV(1) in patients with asthma²
  • Airway resistance measured by IOS during methacholine challenge correlates better with asthma symptoms than traditional spirometric measures implying a higher sensitivity index³
  • Impulse oscillometry provides an effective measure of lung dysfunction in 4-year-old children at risk for persistent asthma⁴
  • Spirometry underestimated the prevalence of lung function abnormalities in comparison to forced oscillation⁵

Refrences

* based on the Bio Burden DIN EN ISO 11737-1: Report 18AA0088 1. Z L Borrill, C M Houghton, A A Woodcock, J Vestbo, and D Singh Medicines Evaluation Unit, North-west Lung Centre, Wythenshawe Hospital, Manchester, UK Br J Clin Pharmacol. 2005 April; 59(4): 379–384. doi: 10.1111/j.1365-2125.2004.02261.x. 2. Yaegashi M, Yalamanchili V, Kaza V, Weedon J, Heurich A, Akerman M. Respir Med. 2007 May;101(5):995-1000. 3. Mansur AH, Manney S, Ayres JG. Resp Med. 2007 Sep 25. Respiratory Medicine, Birmingham Heartlands Hospital NHS Trust, Birmingham, West Midlands, UK. 4. Marotta A, Klinnert, M, Price, M, Larsen, G. Liu, A.H. J Allergy Clin Immunol 2003; 112(2): 317-322. Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, and the Department of Pediatrics, University of Colorado Health Sciences Center, Denver, 80206, USA. 5. Skloot G, Goldman M, Fischler D, Goldman C, Schechter C, Levin S, Teirstein A. Chest. 2004 Apr;125(4):1248-55. Division of Pulmonary and Critical Care Medicine, Mount Sinai School of Medicine, New York, NY, USA.

Learning center

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Service

Service is essential to keep medical equipment operational and safe. Our Nordic service team consists of experienced service technicians stationed across the Nordic countries. Our service technicians are ready to take on your every service need.”

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